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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: Q16781




USC-OGP 2-DE database:  Q16781


Q16781


General information about the entry
View entry in simple text format
Entry nameUBE2N_HUMAN
Primary accession numberP61088
Secondary accession number(s) Q16781
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Ubiquitin-conjugating enzyme E2 N; EC=2.3.2.23 {ECO:0000269|PubMed:20061386}; AltName: Full=Bendless-like ubiquitin-conjugating enzyme; AltName: Full=E2 ubiquitin-conjugating enzyme N; AltName: Full=Ubc13; AltName: Full=UbcH13; AltName: Full=Ubiquitin carrier protein N; AltName: Full=Ubiquitin-protein ligase N;.
Gene nameName=UBE2N
Synonyms=BLU
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.36; Mw=14908
pI=5.74; Mw=14796

Cross-references
UniProtKB/Swiss-ProtP61088; UBE2N_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameUBE2N_HUMAN
Primary accession numberP61088
Secondary accession number(s) Q16781 Q53Y81
Sequence was last modified on April 26, 2004 (version 1)
Annotations were last modified on March 15, 2017 (version 161)
Name and origin of the protein
DescriptionRecName: Full=Ubiquitin-conjugating enzyme E2 N; EC=2.3.2.23 {ECO:0000269|PubMed:20061386}; AltName: Full=Bendless-like ubiquitin-conjugating enzyme; AltName: Full=E2 ubiquitin-conjugating enzyme N; AltName: Full=Ubc13; AltName: Full=UbcH13; AltName: Full=Ubiquitin carrier protein N; AltName: Full=Ubiquitin-protein ligase N;
Gene nameName=UBE2N
Synonyms=BLU
Encoded onName=UBE2N; Synonyms=BLU
Keywords3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; DNA damage; DNA repair; Isopeptide bond; Nucleotide-binding; Nucleus; Reference proteome; Transferase; Ubl conjugation; Ubl conjugation pathway.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD83004; BAA11675.1; -; mRNA
EMBLBT006873; AAP35519.1; -; mRNA
EMBLBC000396; AAH00396.1; -; mRNA
EMBLBC003365; AAH03365.1; -; mRNA
EMBLBC108704; AAI08705.1; -; mRNA
CCDSCCDS31875.1; -; .
PIRJC4894; JC4894; .
RefSeqNP_003339.1; NM_003348.3; .
UniGeneHs.524630; -; .
PDB1J7D; X-ray; 1.85 A; B=1-152
PDB2C2V; X-ray; 2.90 A; B/E/H/K=2-152
PDB3HCT; X-ray; 2.10 A; B=1-152
PDB3HCU; X-ray; 2.60 A; B/D=1-152
PDB3VON; X-ray; 3.15 A; C/E/G/J/L/N/Q/S/U/X/Z/b/e/g/i/l/n/p=3-150
PDB3W31; X-ray; 2.96 A; B=1-152
PDB4DHI; X-ray; 1.80 A; D=1-152
PDB4DHJ; X-ray; 2.35 A; C/G/K/N=1-152
PDB4DHZ; X-ray; 3.11 A; F=1-152
PDB4IP3; X-ray; 2.30 A; B=1-152
PDB4NR3; X-ray; 1.80 A; B=2-150
PDB4NRG; X-ray; 1.95 A; B=1-152
PDB4NRI; X-ray; 2.30 A; B=3-150
PDB4ONL; X-ray; 1.35 A; B=1-152
PDB4ONM; X-ray; 1.35 A; B=1-152
PDB4ONN; X-ray; 1.50 A; B=1-152
PDB4ORH; X-ray; 4.80 A; B/F/J=1-152
PDB4TKP; X-ray; 2.08 A; A=2-152
PDB4WHV; X-ray; 8.30 A; B/E/H/K=1-152
PDB5AIT; X-ray; 3.40 A; B/E=1-152
PDB5AIU; X-ray; 2.21 A; B/E=1-152
PDB5EYA; X-ray; 2.40 A; A/B=1-152
PDBsum1J7D; -; .
PDBsum2C2V; -; .
PDBsum3HCT; -; .
PDBsum3HCU; -; .
PDBsum3VON; -; .
PDBsum3W31; -; .
PDBsum4DHI; -; .
PDBsum4DHJ; -; .
PDBsum4DHZ; -; .
PDBsum4IP3; -; .
PDBsum4NR3; -; .
PDBsum4NRG; -; .
PDBsum4NRI; -; .
PDBsum4ONL; -; .
PDBsum4ONM; -; .
PDBsum4ONN; -; .
PDBsum4ORH; -; .
PDBsum4TKP; -; .
PDBsum4WHV; -; .
PDBsum5AIT; -; .
PDBsum5AIU; -; .
PDBsum5EYA; -; .
ProteinModelPortalP61088; -; .
SMRP61088; -; .
BioGrid113182; 164; .
DIPDIP-29829N; -; .
IntActP61088; 134; .
MINTMINT-5001139; -; .
STRING9606.ENSP00000316176; -; .
BindingDBP61088; -; .
ChEMBLCHEMBL6089; -; .
iPTMnetP61088; -; .
PhosphoSitePlusP61088; -; .
SwissPalmP61088; -; .
BioMutaUBE2N; -; .
DMDM46577660; -; .
OGPQ16781; -; .
REPRODUCTION-2DPAGEIPI00003949; -; .
EPDP61088; -; .
PaxDbP61088; -; .
PeptideAtlasP61088; -; .
PRIDEP61088; -; .
TopDownProteomicsP61088; -; .
DNASU7334; -; .
EnsemblENST00000318066; ENSP00000316176; ENSG00000177889; .
GeneID7334; -; .
KEGGhsa:7334; -; .
CTD7334; -; .
DisGeNET7334; -; .
GeneCardsUBE2N; -; .
HGNCHGNC:12492; UBE2N; .
HPAHPA044976; -; .
MalaCardsUBE2N; -; .
MIM603679; gene; .
neXtProtNX_P61088; -; .
OpenTargetsENSG00000177889; -; .
PharmGKBPA37141; -; .
eggNOGKOG0417; Eukaryota; .
eggNOGCOG5078; LUCA; .
GeneTreeENSGT00540000070023; -; .
HOGENOMHOG000233455; -; .
HOVERGENHBG063308; -; .
InParanoidP61088; -; .
KOK10580; -; .
OMAIDKWSPA; -; .
PhylomeDBP61088; -; .
TreeFamTF101126; -; .
BRENDA2.3.2.B6; 2681; .
ReactomeR-HSA-1169408; ISG15 antiviral mechanism; .
ReactomeR-HSA-168638; NOD1/2 Signaling Pathway; .
ReactomeR-HSA-202424; Downstream TCR signaling; .
ReactomeR-HSA-2871837; FCERI mediated NF-kB activation; .
ReactomeR-HSA-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; .
ReactomeR-HSA-446652; Interleukin-1 signaling; .
ReactomeR-HSA-450302; activated TAK1 mediates p38 MAPK activation; .
ReactomeR-HSA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; .
ReactomeR-HSA-5607764; CLEC7A (Dectin-1) signaling; .
ReactomeR-HSA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; .
ReactomeR-HSA-5693571; Nonhomologous End-Joining (NHEJ); .
ReactomeR-HSA-5693607; Processing of DNA double-strand break ends; .
ReactomeR-HSA-5696395; Formation of Incision Complex in GG-NER; .
ReactomeR-HSA-69473; G2/M DNA damage checkpoint; .
ReactomeR-HSA-8866654; E3 ubiquitin ligases ubiquitinate target proteins; .
ReactomeR-HSA-937039; IRAK1 recruits IKK complex; .
ReactomeR-HSA-937041; IKK complex recruitment mediated by RIP1; .
ReactomeR-HSA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; .
ReactomeR-HSA-975144; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; .
ReactomeR-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; .
SignaLinkP61088; -; .
SIGNORP61088; -; .
UniPathwayUPA00143; -; .
ChiTaRSUBE2N; human; .
EvolutionaryTraceP61088; -; .
GeneWikiUBE2N; -; .
GenomeRNAi7334; -; .
PROPR:P61088; -; .
ProteomesUP000005640; Chromosome 12; .
BgeeENSG00000177889; -; .
CleanExHS_UBE2N; -; .
ExpressionAtlasP61088; baseline and differential; .
GenevisibleP61088; HS; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0001650; C:fibrillar center; IDA:HPA; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0043234; C:protein complex; IDA:MGI; .
GOGO:0031372; C:UBC13-MMS2 complex; IDA:HGNC; .
GOGO:0035370; C:UBC13-UEV1A complex; IDA:UniProtKB; .
GOGO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0043130; F:ubiquitin binding; IDA:HGNC; .
GOGO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central; .
GOGO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central; .
GOGO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB; .
GOGO:0000187; P:activation of MAPK activity; TAS:Reactome; .
GOGO:0006464; P:cellular protein modification process; TAS:ProtInc; .
GOGO:0000729; P:DNA double-strand break processing; IMP:HGNC; .
GOGO:0000724; P:double-strand break repair via homologous recombination; IMP:HGNC; .
GOGO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:Reactome; .
GOGO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; .
GOGO:0070911; P:global genome nucleotide-excision repair; TAS:Reactome; .
GOGO:0016574; P:histone ubiquitination; IMP:HGNC; .
GOGO:0007254; P:JNK cascade; TAS:Reactome; .
GOGO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome; .
GOGO:0045739; P:positive regulation of DNA repair; IMP:HGNC; .
GOGO:0031058; P:positive regulation of histone modification; IMP:HGNC; .
GOGO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:HGNC; .
GOGO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB; .
GOGO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IMP:HGNC; .
GOGO:0006301; P:postreplication repair; IMP:HGNC; .
GOGO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB; .
GOGO:0016567; P:protein ubiquitination; IMP:HGNC; .
GOGO:0006508; P:proteolysis; TAS:ProtInc; .
GOGO:0006282; P:regulation of DNA repair; TAS:ProtInc; .
GOGO:0033182; P:regulation of histone ubiquitination; IMP:HGNC; .
GOGO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; .
GOGO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB; .
Gene3D3.10.110.10; -; 1; .
InterProIPR000608; UBQ-conjugat_E2; .
InterProIPR023313; UBQ-conjugating_AS; .
InterProIPR016135; UBQ-conjugating_enzyme/RWD; .
PfamPF00179; UQ_con; 1; .
SUPFAMSSF54495; SSF54495; 1; .
PROSITEPS00183; UBIQUITIN_CONJUGAT_1; 1; .
PROSITEPS50127; UBIQUITIN_CONJUGAT_2; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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